KMID : 0363120160290040249
|
|
Korean Journal of Pain 2016 Volume.29 No. 4 p.249 ~ p.254
|
|
The acute effect of maximal exercise on plasma beta-endorphin levels in fibromyalgia patients
|
|
Ali Bidari
Banafsheh Ghavidel-Parsa Sahar Rajabi Omid Sanaei Mehrangiz Toutounchi
|
|
Abstract
|
|
|
Background: This study aimed to investigate the effect of strenuous exercise on ¥â-endorphine (¥â-END) level in fibromyalgia (FM) patients compared to healthy subjects.
Methods: We enrolled 30 FM patients and 15 healthy individuals. All study participants underwent a treadmill exercise test using modified Bruce protocol (M.Bruce). The goal of the test was achieving at least 70% of the predicted maximal heart rate (HRMax). The serum levels of ¥â-END were measured before and after the exercise program. Measurements were done while heart rate was at least 70% of its predicted maximum.
Results: The mean ¡¾ the standard deviation (SD) of exercise duration in the FM and control groups were 24.26 ¡¾ 5.29 and 29.06 ¡¾ 3.26 minutes, respectively, indicating a shorter time to achieve the goal heart rate in FM patients (P < 0.003). Most FM patients attained 70% HRMax at lower stages (stage 2 and 3) of M.Bruce compared to the control group (70% versus 6.6%, respectively; P £¼ 0.0001). Compared to healthy subjects, FM patients had lower serum ¥â-END levels both in baseline and post-exercise status (Mean ¡¾ SD: 122.07 ¡¾ 28.56 ¥ìg/ml and 246.55 ¡¾ 29.57 ¥ìg/ml in the control group versus 90.12 ¡¾ 20.91 ¥ìg/ml and 179.80 ¡¾ 28.57 ¥ìg/ml in FM patients, respectively; P £¼ 0.001).
Conclusions: We found that FM patients had lower levels of ¥â-END in both basal and post-exercise status. Exercise increased serum the ¥â-END level in both groups but the average increase in ¥â-END in FM patients was significantly lower than in the control group.
|
|
KEYWORD
|
|
Beta-endorphin, Exercise, Fibromyalgia, Healthy subjects, Pain, Serum
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|